Holding the Shift key will adjust your visuals to make it slightly easier to aim. PC: For Killers playing on PC, you just need to hit the 1 key to ensure the knife is out and then press E to throw it.
Being able to throw the knife is a huge asset for players as it gives them a greater range to make kills from, but how to do it will depend on what platform you’re playing Murder Mystery 2 on. When players are cast into the role of the Killer, they’re given a knife and a simple job - kill as many other players without being killed by the Sheriff, who is armed with a gun.